The links below provide a number of our technical reports on the design, conduct, monitoring, and analysis of clinical trials. These reports are organized into the following categories (a single technical report may appear in multiple categories):

1. •Results about probability models and statistical analysis models useful in RCT
   

2. •General methodology for RCT
   

3. •Noninferiority trials
   

4. •Group sequential stopping rules
   

5. •Adaptive sequential stopping rules
   

6. •Implementation of monitoring plans
   

7. •Frequentist inference following sequential trials
   

8. •Bayesian methods for sequential trials
   

9. •Sequential sampling with time to event (survival) data
   

10. •Sequential sampling with longitudinal data
    

11. •Sequential sampling in RCT evaluating medical diagnostic methods
    

12. •Missing data in RCT
    

13. •Software for design, monitoring, and analysis of sequential RCT